This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.
Pharmacokinetics
Pharmacokinetics
This course is part of Drug Hunting: The Science of Making New Medicines Specialization
Instructors: Erland Stevens, PhD
2,286 already enrolled
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4.9
(37 reviews)
Intermediate level
Recommended experience
12 hours to complete
3 weeks at 4 hours a week
Flexible schedule
Learn at your own pace
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Assessments
15 assignments
Taught in English
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This course is part of the Drug Hunting: The Science of Making New Medicines Specialization
When you enroll in this course, you'll also be enrolled in this Specialization.
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There are 3 modules in this course
Welcome, by the end of the course students will be able to: Summarize the key concepts of pharmacokinetics (PK), ADME (Absorption, Distribution, Metabolism, and Excretion), volume of distribution, half-life and clearance. Differentiate between different routes of drug administration and their impact on PK parameters. Define and describe the influence of transporters, plasma protein binding (PPB) and drug-drug interactions (DDIs) on the PK of a drug molecule. Explain how PK/PD relationships are derived and their importance for defining the anticipated human dose.
What's included
5 videos1 reading4 assignments
What's included
5 videos1 reading6 assignments
What's included
5 videos1 reading5 assignments
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4.9
37 reviews
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Showing 3 of 37
AP
5
Reviewed on Sep 7, 2024
Amazing course for people intending to pursue higher studies in the field of pharmacology
OI
5
Reviewed on Jul 14, 2024
Amazing to-the-point course content, great citations to key articles and questions which are very helpful for permenance. I'm pleased as a medical doctor in drug research. Thanks for this course!
EK
4
Reviewed on Aug 4, 2024
Overall comprehensive basic content, clearly presented. Feedback on quizzes and assignments needs to be clearer and more informative in some cases.
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