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Capstone Project: Advanced AI for Drug Discovery

This course is part of AI for Scientific Research Specialization

Instructor: LearnQuest Network

6,533 already enrolled

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4 modules

Gain insight into a topic and learn the fundamentals.

Intermediate level

Recommended experience

1 week to complete

at 10 hours a week

Flexible schedule

Learn at your own pace

4 modules

Gain insight into a topic and learn the fundamentals.

Intermediate level

Recommended experience

1 week to complete

at 10 hours a week

Flexible schedule

Learn at your own pace

What you'll learn

Analyzing genome sequences to find similarities and identify target subsequences using predctive models.

Skills you'll gain

Tools you'll learn

Pandas (Python Package)

Details to know

Shareable certificate

Add to your LinkedIn profile

Taught in English

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Build your subject-matter expertise

This course is part of the AI for Scientific Research Specialization

When you enroll in this course, you'll also be enrolled in this Specialization.

Learn new concepts from industry experts
Gain a foundational understanding of a subject or tool
Develop job-relevant skills with hands-on projects
Earn a shareable career certificate

There are 4 modules in this course

In this capstone project course, we'll compare genome sequences of COVID-19 mutations to identify potential areas a drug therapy can look to target. The first step in drug discovery involves identifying target subsequences of theirs genome to target. We'll start by comparing the genomes of virus mutations to look for similarities. Then, we'll perform PCA to cut down our number of dimensions and identify the most common features. Next, we'll use K-means clustering in Python to find the optimal number of groups and trace the lineage of the virus. Finally, we'll predict similarity between the sequences and use this to pick a target subsequence. Throughout the course, each section will consist of a programming assignment coupled with a guide video and helpful hints. By the end, you'll be well on your way to discovering ways to combat disease with genome sequencing.

Module details

In this module, we'll start to get familiar with our dataset by performing some basic EDA and comparing genome sequences. By analyzing the mutations of the COVID-19 virus, we'll be able to identify some common properties of the genome that our drug should look to target.

What's included

4 videos1 programming assignment1 discussion prompt1 ungraded lab

4 videosTotal 7 minutes

Welcome to the Course!1 minute
Setting Up the Environment2 minutes
Module Intro1 minute
Introduction to Part I3 minutes

1 programming assignmentTotal 150 minutes

Part I: Comparing Genome Sequences150 minutes

1 discussion promptTotal 10 minutes

Welcome to the Course!10 minutes

1 ungraded labTotal 10 minutes

Programming Assignment Solutions: Part I: Comparing Genome Sequences10 minutes

In this module, we'll continue to work with out genome sequence data - using PCA to identify groups and delicate the most important features. After reducing the number of dimensions in the dataset, we'll be able to use K-means to form clusters and visualize the different areas in 2-D space.

What's included

2 videos1 reading1 programming assignment1 ungraded lab

In this module, we'll cluster the genome sequences using the K-means algorithm. We'll optimize the number of clusters by comparing silhouette scores across a wide variety of inputs to identify the greatest drop-off. Finally, we'll set ourselves up to using prediction pipelines to predict bit scores and drug therapies in the last module.

What's included

2 videos1 programming assignment1 discussion prompt1 ungraded lab

In this module, we'll test a variety of regressors to see which one performs best in predicting bit scores for each genome sequence. Then, we'll use our chosen model to find the genome equines that are most closely related and trace out a possible subsequence to target with a combative drug.