Dr. Wiley develops methods for using data from electronic health records for precision medicine discovery and implementation. She developed computational phenotyping algorithms for use in EHR-linked biobanks, investigated new algorithms for precision dosing of warfarin in African Americans, and has served as the lead informatician on an NIH Cancer Moonshot-funded project to create a comprehensive tobacco cessation service at the University of Colorado Cancer Center. She is a principle investigator in the Colorado Center for Personalized Medicine, an Associate Professor in the Department of Biomedical Informatics, and Chief Data Scientist for Health Data Compass at the University of Colorado Anschutz Medical Campus. She has served as an ex officio member of the American Medical Informatics Association Board of Directors and has chaired the 2022 AMIA Informatics Summit and Vice Chaired the 2019 and 2023 AMIA Annual Symposiums and the 2021 AMIA Informatics Summit.